Nicotinamide phosphoribosyltransferase (NAMPT) activity is essential for survival of resting lymphocytes.

Abstract

NAD biosynthesis is emerging as a key regulator of immune cell functions. Accordingly, inhibitors of the NAD-synthesizing enzyme nicotinamide phosphoribosyltransferase (NAMPT) have anti-inflammatory effects, counteract hematological malignancies and are being tested in clinical trials. Still, their effect on different cell types still waits to be fully… (More)
DOI: 10.1038/icb.2013.85

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