Nicotinamide mononucleotide alters mitochondrial dynamics by SIRT3‐dependent mechanism in male mice

@article{Klimova2019NicotinamideMA,
  title={Nicotinamide mononucleotide alters mitochondrial dynamics by SIRT3‐dependent mechanism in male mice},
  author={N. Klimova and Aaron Long and T. Kristian},
  journal={Journal of Neuroscience Research},
  year={2019},
  volume={97},
  pages={975 - 990}
}
Nicotinamide adenine dinucleotide (NAD+) is a central signaling molecule and enzyme cofactor that is involved in a variety of fundamental biological processes. NAD+ levels decline with age, neurodegenerative conditions, acute brain injury, and in obesity or diabetes. Loss of NAD+ results in impaired mitochondrial and cellular functions. Administration of NAD+ precursor, nicotinamide mononucleotide (NMN), has shown to improve mitochondrial bioenergetics, reverse age‐associated physiological… Expand
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