Nicotinamide mononucleotide alters mitochondrial dynamics by SIRT3‐dependent mechanism in male mice

@article{Klimova2019NicotinamideMA,
  title={Nicotinamide mononucleotide alters mitochondrial dynamics by SIRT3‐dependent mechanism in male mice},
  author={N. Klimova and Aaron Long and T. Kristian},
  journal={Journal of Neuroscience Research},
  year={2019},
  volume={97},
  pages={975 - 990}
}
Nicotinamide adenine dinucleotide (NAD+) is a central signaling molecule and enzyme cofactor that is involved in a variety of fundamental biological processes. NAD+ levels decline with age, neurodegenerative conditions, acute brain injury, and in obesity or diabetes. Loss of NAD+ results in impaired mitochondrial and cellular functions. Administration of NAD+ precursor, nicotinamide mononucleotide (NMN), has shown to improve mitochondrial bioenergetics, reverse age‐associated physiological… Expand
15 Citations
Multi-targeted Effect of Nicotinamide Mononucleotide on Brain Bioenergetic Metabolism
  • 9
NAD+ therapy in age-related degenerative disorders: A benefit/risk analysis
  • 10
Role of NAD+—Modulated Mitochondrial Free Radical Generation in Mechanisms of Acute Brain Injury
  • PDF
Nicotinamide Mononucleotide Attenuates Renal Interstitial Fibrosis After AKI by Suppressing Tubular DNA Damage and Senescence
  • Yan Jia, Xin Kang, +7 authors Li Yang
  • Medicine
  • Frontiers in Physiology
  • 2021
...
1
2
...

References

SHOWING 1-10 OF 97 REFERENCES
NAD+ and sirtuins in aging and disease.
  • 585
  • PDF
NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells
  • 134
  • Highly Influential
  • PDF
Nicotinamide mononucleotide improves energy activity and survival rate in an in vitro model of Parkinson’s disease
  • 23
  • PDF
SIRT3 regulates mitochondrial protein acetylation and intermediary metabolism.
  • 140
  • PDF
Nicotinamide mononucleotide inhibits post-ischemic NAD+ degradation and dramatically ameliorates brain damage following global cerebral ischemia
  • 41
Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice.
  • 233
  • Highly Influential
A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis
  • 949
  • Highly Influential
  • PDF
...
1
2
3
4
5
...