Nicotinamide is an inhibitor of SIRT1 in vitro, but can be a stimulator in cells

@article{Hwang2017NicotinamideIA,
  title={Nicotinamide is an inhibitor of SIRT1 in vitro, but can be a stimulator in cells},
  author={E. Hwang and S. Song},
  journal={Cellular and Molecular Life Sciences},
  year={2017},
  volume={74},
  pages={3347-3362}
}
  • E. Hwang, S. Song
  • Published 2017
  • Biology, Medicine
  • Cellular and Molecular Life Sciences
Nicotinamide (NAM), a form of vitamin B3, plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. These non-redox enzymes include the sirtuin family proteins which deacetylate target proteins while cleaving NAD+ to yield NAM. Since the finding that NAM exerts feedback inhibition to the sirtuin reactions, NAM has been widely used as an inhibitor in the studies where SIRT1, a… Expand
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