Nicotinamide inhibits IRF-1 mRNA induction and prevents IL-1 beta-induced nitric oxide synthase expression in pancreatic beta cells.

@article{Akabane1995NicotinamideII,
  title={Nicotinamide inhibits IRF-1 mRNA induction and prevents IL-1 beta-induced nitric oxide synthase expression in pancreatic beta cells.},
  author={Ayumu Akabane and Ichiro Kato and Shin Takasawa and Michiaki Unno and Hideto Yonekura and Takayuki Yoshimoto and Hiroshi Okamoto},
  journal={Biochemical and biophysical research communications},
  year={1995},
  volume={215 2},
  pages={524-30}
}
Nitric oxide produced by inducible nitric oxide synthase in islets exerts inhibitory and cytotoxic effects on pancreatic beta cells and is therefore thought to be a potent mediator in the pathogenesis of Type I diabetes mellitus. Here, using isolated rat pancreatic islets, we show that high-concentration nicotinamide (20 mM), but not low-concentration nicotinamide (5 mM), attenuates the interleukin-1 beta-evoked inhibition of glucose-induced insulin secretion by preventing the induction of… CONTINUE READING

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