Nicotinamide-induced mitophagy: event mediated by high NAD+/NADH ratio and SIRT1 protein activation.

@article{Jang2012NicotinamideinducedME,
  title={Nicotinamide-induced mitophagy: event mediated by high NAD+/NADH ratio and SIRT1 protein activation.},
  author={So-young Jang and Hyun Tae Kang and Eun Seong Hwang},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 23},
  pages={19304-14}
}
Active autophagy coupled with rapid mitochondrial fusion and fission constitutes an important mitochondrial quality control mechanism and is critical to cellular health. In our previous studies, we found that exposure of cells to nicotinamide causes a decrease in mitochondrial content and an increase in mitochondrial membrane potential (MMP) by activating autophagy and inducing mitochondrial fragmentation. Here, we present evidence to show that the effect of nicotinamide is mediated through an… CONTINUE READING

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