Nicotinamide increases thyroid radiosensitivity by stimulating nitric oxide synthase expression and the generation of organic peroxides.

@article{Robertson2006NicotinamideIT,
  title={Nicotinamide increases thyroid radiosensitivity by stimulating nitric oxide synthase expression and the generation of organic peroxides.},
  author={M. Agote Robertson and P. Finochietto and C. Gamba and M. Dagrosa and M. Viaggi and M. C. Franco and J. J. Poderoso and G. Juvenal and M. Pisarev},
  journal={Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme},
  year={2006},
  volume={38 1},
  pages={
          12-5
        }
}
Differentiated thyroid cancer and hyperthyroidism are treated with radioiodine. However, when the radioisotope dose exceeds certain limits, the patient must be hospitalized to avoid contact with people that would otherwise be exposed to radiation. It would be desirable to obtain a similar therapeutic effect using lower radioiodine doses. Radiosensitizers can be utilized for this purpose. Nicotinamide (NA) increases thyroid radiosensitivity to 131I in both normal and goitrous glands. NA causes a… Expand
Nicotinamide inhibits B lymphocyte activation by disrupting MAPK signal transduction.
Boron neutron capture therapy in cancer: past, present and future.
Optimization of boron neutron capture therapy for the treatment of undifferentiated thyroid cancer.
Zastosowanie niacyny w terapii Niacin in therapy