Nicotinamide increases biosynthesis of ceramides as well as other stratum corneum lipids to improve the epidermal permeability barrier

@article{Tanno2000NicotinamideIB,
  title={Nicotinamide increases biosynthesis of ceramides as well as other stratum corneum lipids to improve the epidermal permeability barrier},
  author={Osamu Tanno and Yukiko Ota and Nobuo Kitamura and Toru Katsube and Shintaro Inoue},
  journal={British Journal of Dermatology},
  year={2000},
  volume={143}
}
  • O. Tanno, Y. Ota, S. Inoue
  • Published 1 September 2000
  • Biology, Chemistry
  • British Journal of Dermatology
Background  Stratum corneum lipids, particularly ceramides, are important components of the epidermal permeability barrier that are decreased in atopic dermatitis and aged skin. Objectives We investigated the effects of nicotinamide, one of the B vitamins, on biosynthesis of sphingolipids, including ceramides and other stratum corneum lipids, in cultured normal human keratinocytes, and on the epidermal permeability barrier in vivo. Methods The rate of sphingolipid biosynthesis was measured by… 
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