Nicotinamide increases biosynthesis of ceramides as well as other stratum corneum lipids to improve the epidermal permeability barrier

@article{Tanno2000NicotinamideIB,
  title={Nicotinamide increases biosynthesis of ceramides as well as other stratum corneum lipids to improve the epidermal permeability barrier},
  author={Osamu Tanno and Yukiko Ota and Nobuo Kitamura and Toru Katsube and Shintaro Inoue},
  journal={British Journal of Dermatology},
  year={2000},
  volume={143}
}
  • O. Tanno, Y. Ota, S. Inoue
  • Published 1 September 2000
  • Biology, Chemistry
  • British Journal of Dermatology
Background  Stratum corneum lipids, particularly ceramides, are important components of the epidermal permeability barrier that are decreased in atopic dermatitis and aged skin. Objectives We investigated the effects of nicotinamide, one of the B vitamins, on biosynthesis of sphingolipids, including ceramides and other stratum corneum lipids, in cultured normal human keratinocytes, and on the epidermal permeability barrier in vivo. Methods The rate of sphingolipid biosynthesis was measured by… 
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187 Citations
Highly Influential Citations
1
Background Citations
49
Methods Citations
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Results Citations
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187 Citations

Ceramides metabolism and impaired epidermal barrier in cutaneous diseases and skin aging: focus on the role of the enzyme PNPLA1 in the synthesis of ω-O-acylceramides and its pathophysiological involvement in some forms of congenital ichthyoses
TLDR
Data from patients with Autosomal Recessive Congenital Ichthyosis and a murine knock-out model showed that the enzyme PNPLA1 is essential for the last step of synthesis of omega-O-acylceramides, and treatments able to increase skin-ceramide levels could improve the epidermal barrier function in aged skin.
Ceramides and Skin Function
TLDR
The link between skin disorders and changes in barrier lipid composition, especially in ceramides, is difficult to prove, however, most skin disorders that have a diminished barrier function present a decrease in total ceramide content with some differences in the ceramide pattern.
Eucalyptus increases ceramide levels in keratinocytes and improves stratum corneum function
TLDR
The results indicate that the increased content of ceramides in the stratum corneum may underlie the therapeutic effect of the Eucalyptus extract and indicate the possibility that macrocarpal A is the key component that stimulates the synthesis of ceramide in the Stratum Corneum.
Topical effects of N-acetyl-L-hydroxyproline on ceramide synthesis and alleviation of pruritus
TLDR
AHYP increased ceramide synthesis by upregulating SPTLC1 in a three-dimensional cultured skin model, and it prevented TEWL increase and alleviated pruritus in human subjects with slight atopic dermatitis.
Phytosphingosine Increases Biosynthesis of Phytoceramide by Uniquely Stimulating the Expression of Dihydroceramide C4-desaturase (DES2) in Cultured Human Keratinocytes.
TLDR
This study demonstrates that PHS plays a fundamental role in strengthening the epidermal permeability barrier by stimulating the overall processes of biosynthesis of all classes of CER in epidermis.
Skin permeation study of liposomes containing nicotinamide for cosmeceutical application
TLDR
It is indicated that the liposomal formulation could increase skin permeation and accumulation of nicotinamide in the skin, and showed potential of liposome as drug skin delivery, however, the clinical efficacy of theliposomal formulations should be evaluated.
[Urea plus ceramides and vitamins: improving the efficacy of a topical urea preparation by addition of ceramides and vitamins].
TLDR
The application of the combination preparation containing urea, vitamins and ceramides for 2 weeks was significantly superior to the urea-only preparation in respect to reduction of transepidermal water loss and skin hydration levels.
Mechanistic Basis and Clinical Evidence for the Applications of Nicotinamide (Niacinamide) to Control Skin Aging and Pigmentation
  • Y. Boo
  • Biology, Medicine
    Antioxidants
  • 2021
TLDR
It is suggested that nicotinamide will be useful as a cosmeceutical ingredient to attenuate skin aging and hyperpigmentation, especially in the elderly or patients with reduced NAD+ pool in the skin due to internal or external stressors.
Dietary constituents are able to play a beneficial role in canine epidermal barrier function
TLDR
It was found that a combination of pantothenate, choline, nicotinamide, histidine and inositol, when fed at supplemented concentrations, was able to significantly reduce TEWL in dogs after 9 weeks.
Improvement by sodium dl-α-tocopheryl-6-O-phosphate treatment of moisture-retaining ability in stratum corneum through increased ceramide levels.
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