Nicotinamide increases biosynthesis of ceramides as well as other stratum corneum lipids to improve the epidermal permeability barrier

  title={Nicotinamide increases biosynthesis of ceramides as well as other stratum corneum lipids to improve the epidermal permeability barrier},
  author={Osamu Tanno and Yukiko Ota and Nobuo Kitamura and Toru Katsube and Shintaro Inoue},
  journal={British Journal of Dermatology},
  • O. Tanno, Y. Ota, S. Inoue
  • Published 1 September 2000
  • Biology, Chemistry
  • British Journal of Dermatology
Background  Stratum corneum lipids, particularly ceramides, are important components of the epidermal permeability barrier that are decreased in atopic dermatitis and aged skin. Objectives We investigated the effects of nicotinamide, one of the B vitamins, on biosynthesis of sphingolipids, including ceramides and other stratum corneum lipids, in cultured normal human keratinocytes, and on the epidermal permeability barrier in vivo. Methods The rate of sphingolipid biosynthesis was measured by… 
Ceramides metabolism and impaired epidermal barrier in cutaneous diseases and skin aging: focus on the role of the enzyme PNPLA1 in the synthesis of ω-O-acylceramides and its pathophysiological involvement in some forms of congenital ichthyoses
Data from patients with Autosomal Recessive Congenital Ichthyosis and a murine knock-out model showed that the enzyme PNPLA1 is essential for the last step of synthesis of omega-O-acylceramides, and treatments able to increase skin-ceramide levels could improve the epidermal barrier function in aged skin.
Ceramides and Skin Function
The link between skin disorders and changes in barrier lipid composition, especially in ceramides, is difficult to prove, however, most skin disorders that have a diminished barrier function present a decrease in total ceramide content with some differences in the ceramide pattern.
Eucalyptus increases ceramide levels in keratinocytes and improves stratum corneum function
The results indicate that the increased content of ceramides in the stratum corneum may underlie the therapeutic effect of the Eucalyptus extract and indicate the possibility that macrocarpal A is the key component that stimulates the synthesis of ceramide in the Stratum Corneum.
Topical effects of N-acetyl-L-hydroxyproline on ceramide synthesis and alleviation of pruritus
AHYP increased ceramide synthesis by upregulating SPTLC1 in a three-dimensional cultured skin model, and it prevented TEWL increase and alleviated pruritus in human subjects with slight atopic dermatitis.
Phytosphingosine Increases Biosynthesis of Phytoceramide by Uniquely Stimulating the Expression of Dihydroceramide C4-desaturase (DES2) in Cultured Human Keratinocytes.
This study demonstrates that PHS plays a fundamental role in strengthening the epidermal permeability barrier by stimulating the overall processes of biosynthesis of all classes of CER in epidermis.
Skin permeation study of liposomes containing nicotinamide for cosmeceutical application
It is indicated that the liposomal formulation could increase skin permeation and accumulation of nicotinamide in the skin, and showed potential of liposome as drug skin delivery, however, the clinical efficacy of theliposomal formulations should be evaluated.
[Urea plus ceramides and vitamins: improving the efficacy of a topical urea preparation by addition of ceramides and vitamins].
The application of the combination preparation containing urea, vitamins and ceramides for 2 weeks was significantly superior to the urea-only preparation in respect to reduction of transepidermal water loss and skin hydration levels.
Mechanistic Basis and Clinical Evidence for the Applications of Nicotinamide (Niacinamide) to Control Skin Aging and Pigmentation
  • Y. Boo
  • Biology, Medicine
  • 2021
It is suggested that nicotinamide will be useful as a cosmeceutical ingredient to attenuate skin aging and hyperpigmentation, especially in the elderly or patients with reduced NAD+ pool in the skin due to internal or external stressors.
Dietary constituents are able to play a beneficial role in canine epidermal barrier function
It was found that a combination of pantothenate, choline, nicotinamide, histidine and inositol, when fed at supplemented concentrations, was able to significantly reduce TEWL in dogs after 9 weeks.


Serine-palmitoyl transferase activity in cultured human keratinocytes.
It is found that cultured human neonatal keratinocytes contain unusually high levels of serine-palmitoyl transferase activity, and that the substrate specificity of keratinocyte SPT may determine the base composition of epidermal sphingolipids.
The formation of competent barrier lipids in reconstructed human epidermis requires the presence of vitamin C.
The results indicate the key role vitamin C plays in the formation of stratum corneum barrier lipids and the improvement of the lipid profile was accompanied by a marked improved of the barrier formation.
Human epidermal lipids: characterization and modulations during differentiation.
These studies: 1) provide new quantitative data about human epidermal lipids; 2) implicate certain classes of lipids for specific functions of the stratum corneum; and, 3) shed light on possible product-precursor relationships of these lipids.
UVB irradiation up-regulates serine palmitoyltransferase in cultured human keratinocytes.
It is demonstrated that CHKs respond to UVB by increasing sphingolipid synthesis, primarily through increases in both LCB2 mRNA and protein levels, leading to increased SPT activity, and suggested further that epidermis up-regulates sphingosine synthesis at both the mRNA andprotein levels in response toUVB.
Decreased level of ceramides in stratum corneum of atopic dermatitis: an etiologic factor in atopic dry skin?
Findings suggest that an insufficiency of ceramides in the stratum corneum is an etiologic factor in atopic dry skin.
Lipid content and lipid type as determinants of the epidermal permeability barrier.
A relationship between the total lipid content of the stratum corneum and barrier function is supported and removal of nonpolar species alone appears to cause only a modest level of barrier disruption, while removal of sphingolipids and free sterols leads to a more profoundlevel of barrier perturbation.
Abnormalities in stratum corneum structure, lipid composition, and desmosome degradation in soap-induced winter xerosis
The results support previous studies demonstrating the importance of desmosomal degradation in desquamation and provide new insights into soap-induced winter xerosis, revealing abnormalities in stratum comeurn lipid composition and organization together with reduced desmosome degradation.
Endotoxin and cytokines increase hepatic sphingolipid biosynthesis and produce lipoproteins enriched in ceramides and sphingomyelin.
Results indicate that LPS and cytokines stimulate hepatic sphingolipid synthesis, which results in an altered structure of circulating lipoproteins and may promote atherogenesis.
Role of ceramide as a lipid mediator of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation.
Ceramide is a lipid mediator that may transduce the action of 1,25-(OH)2D3 on HL-60 cell differentiation and is demonstrated to be independent of sphingosine generation.