Nicotinamide and methionine reduce the liver toxic effect of methotrexate.

  title={Nicotinamide and methionine reduce the liver toxic effect of methotrexate.},
  author={Hans Kroeger and Annette Hauschild and Manuela Ohde and Karl Bache and Wolf P. Voigt and W Thefeldt and Dieter Kr{\"u}ger},
  journal={General pharmacology},
  volume={33 2},
Methotrexate is widely used as a therapeutic agent in different diseases. This therapy is connected with various side effects, including liver toxicity. We have developed a mouse model to demonstrate the toxic effects of methotrexate: mice were given 50 mg/kg acetaminophen, which itself has no effect on the liver. If, additionally, methotrexate is applied, there is an increase in the death rate, as well as in glutamate-oxaloacetate transaminase (GOT) and glutamate-pyruvate transaminase (GPT… CONTINUE READING