Nicotinamide and methionine reduce the liver toxic effect of methotrexate.

@article{Kroeger1999NicotinamideAM,
  title={Nicotinamide and methionine reduce the liver toxic effect of methotrexate.},
  author={H. Kroeger and A. Hauschild and M. Ohde and K. Bache and W. Voigt and W. Thefeldt and D. Kr{\"u}ger},
  journal={General pharmacology},
  year={1999},
  volume={33 2},
  pages={
          203-6
        }
}
  • H. Kroeger, A. Hauschild, +4 authors D. Krüger
  • Published 1999
  • Chemistry, Medicine
  • General pharmacology
  • Methotrexate is widely used as a therapeutic agent in different diseases. This therapy is connected with various side effects, including liver toxicity. We have developed a mouse model to demonstrate the toxic effects of methotrexate: mice were given 50 mg/kg acetaminophen, which itself has no effect on the liver. If, additionally, methotrexate is applied, there is an increase in the death rate, as well as in glutamate-oxaloacetate transaminase (GOT) and glutamate-pyruvate transaminase (GPT… CONTINUE READING

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