Nicotinamide and methionine reduce the liver toxic effect of methotrexate.

@article{Krger1999NicotinamideAM,
  title={Nicotinamide and methionine reduce the liver toxic effect of methotrexate.},
  author={Hans Kr{\"o}ger and Annette Hauschild and Manuela Ohde and Karl Bache and Wolf P. Voigt and W Thefeldt and D. Kr{\"u}ger},
  journal={General pharmacology},
  year={1999},
  volume={33 2},
  pages={
          203-6
        }
}
Methotrexate is widely used as a therapeutic agent in different diseases. This therapy is connected with various side effects, including liver toxicity. We have developed a mouse model to demonstrate the toxic effects of methotrexate: mice were given 50 mg/kg acetaminophen, which itself has no effect on the liver. If, additionally, methotrexate is applied, there is an increase in the death rate, as well as in glutamate-oxaloacetate transaminase (GOT) and glutamate-pyruvate transaminase (GPT… 
Effect of Methotrexate on the Liver Enzymes and Lipid Profile in Adult Female Albino Mice
TLDR
The evaluation of the effects of MTX on some liver enzymes and lipid profile was studied and a significant (p<0.05) increase in serum levels of glutamic oxaloacetate transaminase (GOT) , glutamic pyruric transaminases (GPT), Alkaline phosphatase (ALP) , total cholesterol and triglyceride (TG), however high density lipoprotein (HDL) showed a significant decrease in mice treated by MTX.
Prevention of methotrexate-induced nephrotoxicity by concomitant administration of garlic aqueous extract in rat.
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Pretreatment with garlic significantly improved renal function and increased renal antioxidant enzyme activities and reduced renal oxidative stress and prevented alterations in renal morphology.
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Protective effect of pentoxyfilline in renal toxicity after methotrexate administration.
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TLDR
Results revealed that gentamicin may aggravate indomethacin hepatotoxicity, and methionine managed to ameliorate this effect.
Methotrexate-induced renal oxidative stress in rats: the role of a novel antioxidant caffeic acid phenethyl ester
TLDR
Investigation of the role of caffeic acid phenethyl ester (Caffeic Ester), a novel antioxidant, on methotrexate-induced renal oxidative stress in rats found that it leads to a reduction in antioxidant enzymatic defense capacity and causes lipid peroxidation in renal tissue.
Methotroxate: A friend or a foe? Review article
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The structure, mechanism of action, efficacy, application, metabolism and excertion of the methotroxate have been investigated and a newly established method for the early detection is explained.
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