Nicotinamide and ketamine reduce infarct volume and DNA fragmentation in rats after brain ischemia and reperfusion

@article{Chang2002NicotinamideAK,
  title={Nicotinamide and ketamine reduce infarct volume and DNA fragmentation in rats after brain ischemia and reperfusion},
  author={Mei Ling Chang and Jun Yang and Seyha Kem and Lori K. Klaidman and Taku Sugawara and Pak Hoo Chan and James David Adams},
  journal={Neuroscience Letters},
  year={2002},
  volume={322},
  pages={137-140}
}
The possible ability of nicotinamide and ketamine to decrease infarction volume and DNA fragmentation was investigated in a middle cerebral artery occlusion rat model. DNA fragmentation was measured with an enzyme linked immunoassay. Control infarct volume was 223.8 +/- 10.6 mm(3). Ketamine alone did not alter infarct volume, 233.2 +/- 61.8 mm(3). Nicotinamide alone did not alter infarct volume, 235.2 +/- 62.8 mm(3). The combination of ketamine and nicotinamide decreased infarct volume to 83.8… CONTINUE READING
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