Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae

@article{Anderson2003NicotinamideAP,
  title={Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae},
  author={Rozalyn M. Anderson and Kevin J. Bitterman and Jason G Wood and Oliver Medvedik and David A Sinclair},
  journal={Nature},
  year={2003},
  volume={423},
  pages={181-185}
}
Calorie restriction extends lifespan in a broad range of organisms, from yeasts to mammals. Numerous hypotheses have been proposed to explain this phenomenon, including decreased oxidative damage and altered energy metabolism. In Saccharomyces cerevisiae, lifespan extension by calorie restriction requires the NAD+-dependent histone deacetylase, Sir2 (ref. 1). We have recently shown that Sir2 and its closest human homologue SIRT1, a p53 deacetylase, are strongly inhibited by the vitamin B3… CONTINUE READING
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