Nicotinamide adenine dinucleotide metabolism as an attractive target for drug discovery

  title={Nicotinamide adenine dinucleotide metabolism as an attractive target for drug discovery},
  author={J. Khan and F. Forouhar and X. Tao and L. Tong},
  journal={Expert Opinion on Therapeutic Targets},
  pages={695 - 705}
  • J. Khan, F. Forouhar, +1 author L. Tong
  • Published 2007
  • Biology, Medicine
  • Expert Opinion on Therapeutic Targets
  • Nicotinamide adenine dinucleotide (NAD+) has crucial roles in many cellular processes, both as a coenzyme for redox reactions and as a substrate to donate ADP-ribose units. Enzymes involved in NAD+ metabolism are attractive targets for drug discovery against a variety of human diseases, including cancer, multiple sclerosis, neurodegeneration and Huntington’s disease. A small-molecule inhibitor of nicotinamide phosphoribosyltransferase, an enzyme in the salvage pathway of NAD+ biosynthesis, is… CONTINUE READING
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