• DOI:10.1517/14728222.11.5.695
Corpus ID: 6490887

Nicotinamide adenine dinucleotide metabolism as an attractive target for drug discovery

@article{Khan2007NicotinamideAD,
  title={Nicotinamide adenine dinucleotide metabolism as an attractive target for drug discovery},
  author={J. Khan and F. Forouhar and X. Tao and L. Tong},
  journal={Expert Opinion on Therapeutic Targets},
  year={2007},
  volume={11},
  pages={695 - 705}
}

J. Khan, F. Forouhar, +1 author L. Tong

Published 2007

Biology, Medicine

Expert Opinion on Therapeutic Targets

Nicotinamide adenine dinucleotide (NAD+) has crucial roles in many cellular processes, both as a coenzyme for redox reactions and as a substrate to donate ADP-ribose units. Enzymes involved in NAD+ metabolism are attractive targets for drug discovery against a variety of human diseases, including cancer, multiple sclerosis, neurodegeneration and Huntington’s disease. A small-molecule inhibitor of nicotinamide phosphoribosyltransferase, an enzyme in the salvage pathway of NAD+ biosynthesis, is… CONTINUE READING

View on Taylor & Francis

tonglab.biology.columbia.edu

Save to Library

Create Alert

Cite

Launch Research Feed