Nicotinamide adenine dinucleotide metabolism as an attractive target for drug discovery

  title={Nicotinamide adenine dinucleotide metabolism as an attractive target for drug discovery},
  author={Javed A. Khan and Farhad Forouhar and Xiao Tao and Liang Tong},
  journal={Expert Opinion on Therapeutic Targets},
  pages={695 - 705}
Nicotinamide adenine dinucleotide (NAD+) has crucial roles in many cellular processes, both as a coenzyme for redox reactions and as a substrate to donate ADP-ribose units. Enzymes involved in NAD+ metabolism are attractive targets for drug discovery against a variety of human diseases, including cancer, multiple sclerosis, neurodegeneration and Huntington’s disease. A small-molecule inhibitor of nicotinamide phosphoribosyltransferase, an enzyme in the salvage pathway of NAD+ biosynthesis, is… 
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    Current opinion in drug discovery & development
  • 2006
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The development of nicotinamide is described as a novel agent that is critical for modulating cellular metabolism, plasticity, longevity, and inflammatory microglial function as well as for influencing cellular life span.
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