Nicotinamide adenine dinucleotide (NAD) and its metabolites inhibit T lymphocyte proliferation: role of cell surface NAD glycohydrolase and pyrophosphatase activities.

@article{Bortell2001NicotinamideAD,
  title={Nicotinamide adenine dinucleotide (NAD) and its metabolites inhibit T lymphocyte proliferation: role of cell surface NAD glycohydrolase and pyrophosphatase activities.},
  author={Rita Bortell and Joel Moss and Robert C. McKenna and Mark R. Rigby and Dena Niedzwiecki and Linda A. Stevens and Walter A. Patton and John P. Mordes and Dale L. Greiner and Aldo A. Rossini},
  journal={Journal of immunology},
  year={2001},
  volume={167 4},
  pages={2049-59}
}
The presence of NAD-metabolizing enzymes (e.g., ADP-ribosyltransferase (ART)2) on the surface of immune cells suggests a potential immunomodulatory activity for ecto-NAD or its metabolites at sites of inflammation and cell lysis where extracellular levels of NAD may be high. In vitro, NAD inhibits mitogen-stimulated rat T cell proliferation. To investigate the mechanism of inhibition, the effects of NAD and its metabolites on T cell proliferation were studied using ART2a+ and ART2b+ rat T cells… CONTINUE READING

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