Nicotinamide Prevents Interleukin-1 Effects on Accumulated Insulin Release and Nitric Oxide Production in Rat Islets of Langerhans

@article{Andersen1994NicotinamidePI,
  title={Nicotinamide Prevents Interleukin-1 Effects on Accumulated Insulin Release and Nitric Oxide Production in Rat Islets of Langerhans},
  author={H. Andersen and K. J{\o}rgensen and J. Egeberg and T. Mandrup-Poulsen and J. Nerup},
  journal={Diabetes},
  year={1994},
  volume={43},
  pages={770 - 777}
}
Nicotinamide (NA) prevents macrophage- and interleukin-1 (IL-1)-mediated β-cell damage in vitro as well as diabetes development in animal models of insulin-dependent diabetes mellitus (IDDM). IL-1 β-mediated inhibition of insulin release and damage to β-cells are associated with intracellular production of nitric oxide (NO) radicals. Therefore, we studied whether NA prevented IL-1 β-induced islet NO production, measured as nitrite release from isolated rat islets, and, if so, whether this… Expand
Cytokine-induced PGE2 formation is reduced from iNOS deficient murine islets
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 60 REFERENCES
Interleukin 1 is Potent Modulator of Insulin Secretion from Isolated Rat Islets of Langerhans
Interleukin 1 Inhibits Insulin Secretion From Isolated Perifused Rat Islets
Islet Cell DNA Is a Target of Inflammatory Attack by Nitric Oxide
...
1
2
3
4
5
...