Nicotinamide N-oxides as CXCR2 antagonists.

  title={Nicotinamide N-oxides as CXCR2 antagonists.},
  author={Neil S Cutshall and Rocky Ursino and Kristin A Kucera and John Latham and Nathan C. Ihle},
  journal={Bioorganic & medicinal chemistry letters},
  volume={11 14},
A series of nicotinamide N-oxides was synthesized and shown to be novel, potent, and selective antagonists of the CXCR2 receptor. Furthermore, these compounds showed significant functional activity against GRO-alpha-driven human neutrophil chemotaxis. Compounds of this class may be useful for the treatment of inflammatory, auto-immune, and allergic disorders.