Nicotinamide N-methyltransferase enhances the capacity of tumorigenesis associated with the promotion of cell cycle progression in human colorectal cancer cells.

@article{Xie2014NicotinamideNE,
  title={Nicotinamide N-methyltransferase enhances the capacity of tumorigenesis associated with the promotion of cell cycle progression in human colorectal cancer cells.},
  author={Xinyou Xie and Haitao Yu and Yanzhong Wang and Yanwen Zhou and Guiling Li and Zhi Ruan and Fengying Li and Xiuhong Wang and Huixing Liu and Jun Zhang},
  journal={Archives of biochemistry and biophysics},
  year={2014},
  volume={564},
  pages={52-66}
}
Nicotinamide N-methyltransferase (NNMT), an enzyme involved in the biotransformation and detoxification of many drugs and xenobiotic compounds, has been found to be overexpressed in several malignancies, including colorectal cancer. However, the biological function of NNMT and the related mechanisms in colorectal cancer have not been elucidated. In the present study, we investigated the effects of NNMT on tumorigenesis by overexpressing NNMT in the human colorectal cancer cells line SW480 which… CONTINUE READING

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