Nicotinamide Adenine Dinucleotide (NAD+) Repletion Attenuates Bupivacaine-Induced Neurotoxicity

@article{Zheng2013NicotinamideA,
  title={
Nicotinamide Adenine Dinucleotide (NAD+) Repletion Attenuates Bupivacaine-Induced Neurotoxicity},
  author={Ting Zheng and Shi Yuan Xu and Shu Zhou and Lu Lai and Le Li},
  journal={Neurochemical Research},
  year={2013},
  volume={38},
  pages={1880-1894}
}
Bupivacaine is one of the most toxic local anesthetics but the mechanisms underlying its neurotoxicity are still unclear. Intracellular nicotinamide adenine dinucleotide (NAD+) depletion has been demonstrated to play an essential role in neuronal injury. In the present study, we investigated whether intracellular NAD+ depletion contributes to bupivacaine-induced neuronal injury and whether NAD+ repletion attenuates the injury in SH-SY5Y cells. First, we evaluated the intracellular NAD+ content… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 46 REFERENCES

NAD+ depletion is necessary and sufficient for poly(ADP-ribose) polymerase-1-mediated neuronal death.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2010
VIEW 10 EXCERPTS
HIGHLY INFLUENTIAL

Cytotoxicity of local anesthetics in human neuronal cells.

  • Anesthesia and analgesia
  • 2009
VIEW 7 EXCERPTS
HIGHLY INFLUENTIAL

NAD and axon degeneration: from the Wlds gene to neurochemistry.

  • Cell adhesion & migration
  • 2009
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Bupivacaine induces apoptosis via ROS in the Schwann cell line.

  • Journal of dental research
  • 2005
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL