Nicotinamide (vitamin B3) as an effective antioxidant against oxidative damage in rat brain mitochondria.

@article{Kamat1999NicotinamideB,
  title={Nicotinamide (vitamin B3) as an effective antioxidant against oxidative damage in rat brain mitochondria.},
  author={Jayashree P. Kamat and Thomas P.A. Devasagayam},
  journal={Redox report : communications in free radical research},
  year={1999},
  volume={4 4},
  pages={179-84}
}
Nicotinamide (vitamin B3) an endogenous metabolite, showed significant inhibition of oxidative damage induced by reactive oxygen species (ROS) generated by ascorbate-Fe2+ and photosensitization systems in rat brain mitochondria. It protected against both protein oxidation and lipid peroxidation, at millimolar concentrations. Inhibition was more pronounced against oxidation of proteins than peroxidation of lipids. Chemically related endogenous compounds, tryptophan and isonicotinic acid, showed… CONTINUE READING