Nicotinamide: a potential addition to the anti‐psoriatic weaponry

@article{Namazi2003NicotinamideAP,
  title={Nicotinamide: a potential addition to the anti‐psoriatic weaponry},
  author={Mohammad Reza Namazi},
  journal={The FASEB Journal},
  year={2003},
  volume={17},
  pages={1377 - 1379}
}
  • M. Namazi
  • Published 1 August 2003
  • Biology
  • The FASEB Journal
Psoriasis is an inflammatory disorder characterized by a T helper type 1 cell cytokine pattern. Increased expression of adhesion molecules, prominent neutrophil accumulation, and increased production of nitric oxide are characteristics of this disorder. Moreover, histamine and proteases are supposed to participate in the pathogenesis of psoriasis. Nicotinamide is an inhibitor of poly (ADP‐ribose) polymerase‐1 (PARP‐1) that, through enhancement of nuclear kappa B‐mediated transcription, plays a… 
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