Nicotinamide: a potential addition to the anti‐psoriatic weaponry

  title={Nicotinamide: a potential addition to the anti‐psoriatic weaponry},
  author={Mohammad Reza Namazi},
  journal={The FASEB Journal},
  pages={1377 - 1379}
  • M. Namazi
  • Published 1 August 2003
  • Biology
  • The FASEB Journal
Psoriasis is an inflammatory disorder characterized by a T helper type 1 cell cytokine pattern. Increased expression of adhesion molecules, prominent neutrophil accumulation, and increased production of nitric oxide are characteristics of this disorder. Moreover, histamine and proteases are supposed to participate in the pathogenesis of psoriasis. Nicotinamide is an inhibitor of poly (ADP‐ribose) polymerase‐1 (PARP‐1) that, through enhancement of nuclear kappa B‐mediated transcription, plays a… 

Cannabinoids, loratadine and allopurinol as novel additions to the antipsoriatic ammunition

  • M. Namazi
  • Biology, Medicine
    Journal of the European Academy of Dermatology and Venereology : JEADV
  • 2005
Cannabinoids, cannabinoids and allopurinol are introduced, which exert inhibitory effects on antigen processing and macrophage/T‐cell interaction and also on the release of IL‐2, TNF‐α and nitric oxide from immune cells.

Cetirizine and allopurinol as novel weapons against cellular autoimmune disorders.

  • M. Namazi
  • Biology, Medicine
    International immunopharmacology
  • 2004

Nitric oxide may directly induce the psoriatic disease process via suppression of keratinocyte apoptosis and induction of keratinocyte hyperproliferation

The apoptosis -suppressant effect of NO is suggested as another potential role for NO in inducing the psoriatic disease process.

HypothesisThe Beneficial and Detrimental Effects of Linoleic Acid on Autoimmune Disorders

Taken together, linoleic acid, the major PUFA of maize oil, could have therapeutic efficacy against cellular autoimmune disorders and excessive intake of linolesic acid may aggravate type 2 autoimmune disorders.

Diverse therapeutic efficacies and more diverse mechanisms of nicotinamide

NAM, by itself or through altering metabolic balance of NAD+ and tryptophan, modulates mitochondrial function and activities of many molecules and thereby positively affects cell viability and metabolic functions and appears to be quite safe with limited possibility of side effects which are related to NAM’s metabolites.

The Potential Anti-Psoriatic Effects of Jojoba Extract

It is proposed that jojoba extract may be a useful addition to anti-psoriatic weaponry because of its anti-inflammatory properties.

Nicotinamide Inhibits Vasculogenic Mimicry, an Alternative Vascularization Pathway Observed in Highly Aggressive Melanoma

Nicotinamide effectively inhibited the formation of VM structures and destroyed already formed ones, in a dose-dependent manner, and remarkably, VM formation capacity remained suppressed even one month after the complete withdrawal of Nicotimamid.

Cissampelos sympodialis Eichl (Menispermaceae) leaf extract as a possible novel and safe treatment for psoriasis.

  • A. FeilyM. Namazi
  • Biology, Medicine
    Sao Paulo medical journal = Revista paulista de medicina
  • 2009
This immunological pathway is stimulated by interleukin-12 (IL-12) released from activated dendritic cells and by exposure of T cells to type 1 cytokines during maturation.



Synergistic effects of thalidomide and poly(ADP-ribose) polymerase inhibition on type II collagen-induced arthritis in mice

Type II collagen-induced arthritis can be suppressed by the simultaneous inhibition of TNF-α, PARP, and NADPH oxidase, and the combined application of thalidomide and NAA caused a powerful synergy inhibition of arthritis.

Nicotinamide inhibits nitric oxide synthase mRNA induction in activated macrophages.

Nicotinamide, an inhibitor of ADP-ribosylation, prevented NO synthase induction in RAW 264.7 cells after stimulation with interferon gamma (IFN-gamma) and lipopolysaccharide (LPS) and the level of NO synth enzyme mRNA was measured by Northern-blot analysis and it was found that nicotinamide prevents expression ofNO synthase mRNA in IFN-Gamma- and LPS-stimulated cells.

Novel Therapies for Psoriasis

Three systemic medications currently are approved worldwide for the treatment of moderate to severe forms of psoriasis, namely cyclosporine, methotrexate and acitretin, and the need for more specific systemic therapy, targeting the T lymphocyte is now well known.

The immunologic basis for the treatment of psoriasis with new biologic agents.

  • J. Krueger
  • Biology, Medicine
    Journal of the American Academy of Dermatology
  • 2002
Critical steps in immunologic activation include Langerhans cell maturation (activation), T-cell activation, differentiation and expansion of type 1 T cells, selective trafficking of activated T cells to skin, and induction of an inflammatory cytokine and chemokine cascade in skin lesions.

Nicotinamide increases biosynthesis of ceramides as well as other stratum corneum lipids to improve the epidermal permeability barrier

Nicotinamide improved the permeability barrier by stimulating de novo synthesis of ceramides, with upregulation of serine palmitoyltransferase (SPT) and other intercellular lipids.

Studies on mast cells and histamine release in psoriasis: the effect of ranitidine.

The biochemical findings together with the clinical effect of ranitidine indicate that histamine may be involved in the pathophysiology of psoriasis, and suggests that skin mast cells in active Psoriasis are functionally hyperreactive.

Recent developments in the understanding of the pathogenesis of psoriasis

  • Ortonne
  • Medicine, Biology
    The British journal of dermatology
  • 1999
Further research will help to identify the susceptibility genes involved in psoriasis and provide a more complete understanding of the immunological basis of the disease, which should lead to the development of targeted therapies with improved efficacy and tolerability compared with some currently available treatments.

The Therapeutic Potential of Poly(ADP-Ribose) Polymerase Inhibitors

The double-edged sword roles of PARP in DNA damage signaling and cell death are reviewed and the underlying mechanisms of the anti-inflammatory effects ofPARP inhibitors are summarized.

Role of ceramide as a lipid mediator of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation.

Ceramide is a lipid mediator that may transduce the action of 1,25-(OH)2D3 on HL-60 cell differentiation and is demonstrated to be independent of sphingosine generation.