Nicorandil suppressed ventricular arrhythmias in a canine model of myocardial ischaemia.

@article{Vgh1996NicorandilSV,
  title={Nicorandil suppressed ventricular arrhythmias in a canine model of myocardial ischaemia.},
  author={{\'A}gnes V{\'e}gh and K Gy{\"o}rgyi and Julius Gy Papp and Kazushige Sakai and James Roy Parratt},
  journal={European journal of pharmacology},
  year={1996},
  volume={305 1-3},
  pages={163-8}
}
These experiments were designed to explore the possibility that a K+ channel opener which also donates nitric oxide to the myocardium (nicorandil) may modify ischaemia-induced ventricular arrhythmias in a large animal model. In mongrel dogs anaesthetised with chloralose-urethane and thoracotomised, a side branch of the left anterior descending artery was catheterised for the local intracoronary infusion of nicorandil (2.5 micrograms kg-1 min-1 for 20 min prior to coronary artery occlusion and… CONTINUE READING
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