Nickel translocation between metallochaperones HypA and UreE in Helicobacter pylori.

@article{Yang2014NickelTB,
  title={Nickel translocation between metallochaperones HypA and UreE in Helicobacter pylori.},
  author={Xinming Yang and Hongyan Li and Tianfan Cheng and Wei Xia and Yau-Tsz Lai and Hongzhe Sun},
  journal={Metallomics : integrated biometal science},
  year={2014},
  volume={6 9},
  pages={1731-6}
}
Incorporation of nickel ions to the active sites of urease and hydrogenase is prerequisite for the appropriate functions of the metalloenzymes. Such a process requires the participation of several accessory proteins. Interestingly, some of them are shared by the two enzymes in their maturation processes. In this work, we characterized the molecular details of the interaction of metallochaperones UreE and HypA in Helicobacter pylori. We show by chemical cross-linking and static light scattering… CONTINUE READING