Nickel-specific T lymphocyte clones derived from allergic nickel-contact dermatitis lesions in man: heterogeneity based on requirement of dendritic antigen-presenting cell subsets.

@article{Kapsenberg1987NickelspecificTL,
  title={Nickel-specific T lymphocyte clones derived from allergic nickel-contact dermatitis lesions in man: heterogeneity based on requirement of dendritic antigen-presenting cell subsets.},
  author={Martien L. Kapsenberg and Pieter Res and Jan Dositheus Bos and A Schootemijer and Marcel B. M. Teunissen and W C van Schooten},
  journal={European journal of immunology},
  year={1987},
  volume={17 6},
  pages={861-5}
}
Inflammatory skin T cells were cloned in an antigen-independent way from lesions of patients with experimentally induced nickel-contact dermatitis. In three experiments 7-15% of the CD4+8- T lymphocyte clones (TLC) appeared to be specific for nickel in a proliferation assay. These proliferative response of nickel-specific TLC required the presence of antigen-presenting cells (APC) and were restricted by HLA class II molecules. All TLC recognized nickel presented by APC from epidermal skin… CONTINUE READING