Nickel-induced IL-10 down-regulates Th1- but not Th2-type cytokine responses to the contact allergen nickel.

@article{Minang2006NickelinducedID,
  title={Nickel-induced IL-10 down-regulates Th1- but not Th2-type cytokine responses to the contact allergen nickel.},
  author={Jacob Taku Minang and Ir{\'e}ne Arestr{\"o}m and Bartek Zuber and Gunilla J{\"o}nsson and Marita Troye-Blomberg and Niklas Ahlborg},
  journal={Clinical and experimental immunology},
  year={2006},
  volume={143 3},
  pages={494-502}
}
Whereas the involvement of Th1- and Th2-type cytokines in contact allergy to nickel (Ni) is well documented, the role of the regulatory cytokine IL-10 is less clear. We therefore investigated the impact of IL-10 on Ni-induced Th1- (IFN-gamma) and Th2-type (IL-4 and IL-13) cytokine responses in human peripheral blood mononuclear cells (PBMC). PBMC from 15 blood donors with reactivity to Ni (Ni-PBMC) and 8 control donors devoid of reactivity (control PBMC) were stimulated with Ni and the… CONTINUE READING

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