Nickel-catalyzed highly regioselective multicomponent coupling of ynamides, aldehydes, and silane: a new access to functionalized enamides.

@article{Saito2008NickelcatalyzedHR,
  title={Nickel-catalyzed highly regioselective multicomponent coupling of ynamides, aldehydes, and silane: a new access to functionalized enamides.},
  author={Nozomi Saito and Tomoyuki Katayama and Yoshihiro Sato},
  journal={Organic letters},
  year={2008},
  volume={10 17},
  pages={3829-32}
}
A new method for preparation of functionalized enamides by a nickel-catalyzed multicomponent coupling of ynamides, aldehydes, and silane has been developed. The coupling reaction proceeded in the presence of a nickel-IMes catalyst to give the corresponding gamma-silyloxyenamide derivative, which has an allylic alcohol moiety in the molecule, in a highly… CONTINUE READING