Nickel-catalyzed direct C-H trifluoroethylation of heteroarenes with trifluoroethyl iodide.

@article{Yan2017NickelcatalyzedDC,
  title={Nickel-catalyzed direct C-H trifluoroethylation of heteroarenes with trifluoroethyl iodide.},
  author={Shengyi Yan and Zhuo-Zhuo Zhang and Bing‐Feng Shi},
  journal={Chemical communications},
  year={2017},
  volume={53 74},
  pages={
          10287-10290
        }
}
A highly selective nickel-catalyzed C-H trifluoroethylation of heteroarenes was developed with the assistance of a monodentate directing group. This protocol provides efficient access to various trifluoroethyl-substituted heteroarenes, including indoles, pyrroles, furans, and thiophenes, with commercially available CF3CH2I as an alkylation reagent. This robust catalytic procedure is scalable and tolerates a broad range of functional groups. Moreover, multifluoroalkylation of indoles is also… 
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