Nickel-(II)-Catalyzed N-Formylation and N-Acylation of Amines.


A highly efficient protocol of Ni(II) metal complex, [Ni(quin)2], catalyzing N-formylation and N-acylation of amines with moderate to excellent yields, using N,N-dimethylformamide and N,N-dimethylacetamide in the presence of imidazole, is described here. The protocol shows broad substrate scope for aliphatic, aromatic, and heterocyclic amines.

DOI: 10.1021/acs.orglett.7b00660

Cite this paper

@article{Sonawane2017NickelIICatalyzedNA, title={Nickel-(II)-Catalyzed N-Formylation and N-Acylation of Amines.}, author={Rahul B Sonawane and Nishant K Rasal and Sangeeta V Jagtap}, journal={Organic letters}, year={2017}, volume={19 8}, pages={2078-2081} }