Nickel-Catalyzed Formal Homocoupling of Methoxyarenes for the Synthesis of Symmetrical Biaryls via C-O Bond Cleavage.

Abstract

A new method has been developed for the nickel-catalyzed homocoupling of methoxyarenes via C-O bond cleavage using a diboron reagent. The use of 1,3-dicyclohexylimidazol-2-ylidene as a ligand was found to be critical to the success of the reaction. This new method allows the synthesis of a wide range of biaryl compounds.

DOI: 10.1021/acs.orglett.5b03151

Cite this paper

@article{Nakamura2015NickelCatalyzedFH, title={Nickel-Catalyzed Formal Homocoupling of Methoxyarenes for the Synthesis of Symmetrical Biaryls via C-O Bond Cleavage.}, author={Keisuke Nakamura and Mamoru Tobisu and Naoto Chatani}, journal={Organic letters}, year={2015}, volume={17 24}, pages={6142-5} }