Nickel Allergy and Our Children's Health: A Review of Indexed Cases and a View of Future Prevention

  title={Nickel Allergy and Our Children's Health: A Review of Indexed Cases and a View of Future Prevention},
  author={Sharon E Jacob and Alina Goldenberg and Janice L. Pelletier and Luz Fonacier and Richard P. Usatine and Nanette B. Silverberg},
  journal={Pediatric Dermatology},
Nickel is the leading cause of allergic contact dermatitis (ACD) from early childhood through adolescence. Studies have shown that skin piercings and other nickel‐laden exposures can trigger the onset of nickel ACD in those who are susceptible. Nickel ACD causes a vast amount of cutaneous disease in children. Cases of nickel ACD in children have been reported in peer‐reviewed literature from 28 states. Common items that contain inciting nickel include jewelry, coins, zippers, belts, tools, toys… 

Nickel Allergic Contact Dermatitis: Identification, Treatment, and Prevention

Data point to nickel exposure as a trigger for elicitation of Ni-ACD and provide evidence that legislation can have a favorable effect on the economic and medical health of a population.

Identification of Unreported Sources of Objects Containing High Release Nickel

The United States could potentially save $5.7 billion annually in health care costs, extrapolating current cost-saving data from Denmark post nickel regulation, by implementing similar regulation to that of the European Union (EU).

Hidden risks in toys: A systematic review of pediatric toy contact dermatitis

There is still an unmet need for observation of this segment of industry for labeling of contents and ongoing surveillance of contact dermatitis in children's toys.

What We Have Learned–Milestones in Pediatric Contact Dermatitis

ACD is likely underrecognized and underdiagnosed in pediatric patients, including infants and young children, and providers should keep patient-specific factors and emerging trends in mind when addressing suspected ACD.

Belt Buckles—Increasing Awareness of Nickel Exposure in Children: A Case Report

Allergic contact dermatitis in 12 children with peri-umbilical nickel dermatitis (with and without generalized involvement) caused by dimethylglyoxime-positive belt buckles is described.

The “Jewelry Addict”: Allergic Contact Dermatitis from Repetitive Multiple Children's Jewelry Exposures

The case illustrates the importance of investigating a range of different types of allergens when evaluating for jewelry sensitivity in children with frequent use of accessories, including rubber jewelry, plastics, dyed yarns, beads, metals, and ceramics.

Pediatric patch testing: A 10-year retrospective study.



Nickel and Cobalt Release From Children’s Toys Purchased in Denmark and the United States

Toys are a commonly overlooked source of nickel exposure and sensitization, and the parents of children with positive nickel patch test reactions should be told that toys may release nickel and be a potential chemical source in the manifestation of allergic contact dermatitis.

Nickel Contact Hypersensitivity in Children

It is posited that the presence of a positive family history may be a positive predictor of nickel allergic contact dermatitis, requiring nickel avoidance, especially in atopic children.

Nickel hypersensitivity in the orthodontic patient.

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Characteristics of nickel-allergic dermatitis patients seen in private dermatology clinics in Denmark: a questionnaire study.

It is concluded that nickel allergy has decreased among young females with dermatitis due to the nickel regulation in Denmark.

Nickel coinage in the United States: the history of a common contact allergen.

The history of nickel as a 3- and 5-cent piece and as the base metal used in most of the coins currently in circulation are discussed.

Allergic Contact Dermatitis in Children: Review of the Past Decade

The relationship between ACD and atopic dermatitis (AD) is complicated with conflicting reports of prevalence in the literature; however, in a patient with dermatitis not responding to traditional therapies, or with new areas of involvement, ACD should be considered as part of the work-up.

Nickel allergy and hand dermatitis in a stratified sample of the Danish female population: an epidemiological study including a statistic appendix.

In future efforts to reduce direct skin contact with nickel, the close relation between nickel allergy and hand eczema should be the main argument and statistical methods based on the incidence density will be useful in the evaluation of efforts.

Nickel contact dermatitis in children.

Nickel Allergy: Localized, Id, and Systemic Manifestations in Children

Four children are presented to illustrate the different presentations of nickel allergy confirmed by patch testing and localized, id, and systemic nickel reactions are reviewed, as well as the diagnosis and management of nickel allergic contact dermatitis.