Niche-specific regulation of central metabolic pathways in a fungal pathogen

@article{Barelle2006NichespecificRO,
  title={Niche-specific regulation of central metabolic pathways in a fungal pathogen},
  author={Caroline Jane Barelle and Claire L. Priest and Donna M MacCallum and Neil A R Gow and Frank C. Odds and Alistair J P Brown},
  journal={Cellular Microbiology},
  year={2006},
  volume={8},
  pages={961 - 971}
}
To establish an infection, the pathogen Candida albicans must assimilate carbon and grow in its mammalian host. This fungus assimilates six-carbon compounds via the glycolytic pathway, and two-carbon compounds via the glyoxylate cycle and gluconeogenesis. We address a paradox regarding the roles of these central metabolic pathways in C. albicans pathogenesis: the glyoxylate cycle is apparently required for virulence although glyoxylate cycle genes are repressed by glucose at concentrations… CONTINUE READING
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Temporal events

  • D. M. MacCallum, F. C. Odds
  • 2005
Highly Influential
4 Excerpts

Transcrip - tional response of Candida albicans upon internalization by macrophages

  • F. C. Odds
  • Eukaryot Cell
  • 2005
Highly Influential
2 Excerpts

Candida and Candidiasis

  • R. A. Calderone
  • 2002
Highly Influential
6 Excerpts

encoding phosphoenolpyruvate carboxykinase of the fungal pathogen Candida albicans

  • M. C. Lorenz, G. R. Fink
  • 2001
Highly Influential
9 Excerpts

Candida and Candidosis, 2nd edn

  • F. C. Odds
  • 1988
Highly Influential
6 Excerpts

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