Niche-specific regulation of central metabolic pathways in a fungal pathogen

  title={Niche-specific regulation of central metabolic pathways in a fungal pathogen},
  author={Caroline Jane Barelle and Claire L. Priest and Donna M MacCallum and Neil A R Gow and Frank C. Odds and Alistair J P Brown},
  journal={Cellular Microbiology},
  pages={961 - 971}
To establish an infection, the pathogen Candida albicans must assimilate carbon and grow in its mammalian host. This fungus assimilates six-carbon compounds via the glycolytic pathway, and two-carbon compounds via the glyoxylate cycle and gluconeogenesis. We address a paradox regarding the roles of these central metabolic pathways in C. albicans pathogenesis: the glyoxylate cycle is apparently required for virulence although glyoxylate cycle genes are repressed by glucose at concentrations… CONTINUE READING
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