Niche regulation of hematopoietic stem cells in the endosteum.

  title={Niche regulation of hematopoietic stem cells in the endosteum.},
  author={Fumio Arai and Hiroki Yoshihara and Kentaro Hosokawa and Yuka Nakamura and Yumiko Gomei and Hiroko Iwasaki and Toshio Suda},
  journal={Annals of the New York Academy of Sciences},
During postnatal life, the bone marrow (BM) supports both the self-renewal and differentiation of hematopoietic stem cells (HSCs) in specialized niches. The interaction of HSCs with their niches also regulates the quiescence of HSCs. HSC quiescence is critical to ensure lifelong hematopoiesis and to protect the HSC pool from myelotoxic insult and premature exhaustion under conditions of hematopoietic stress. Here we identified long-term (LT)-HSCs expressing the thrombopoietin (THPO) receptor… CONTINUE READING