Niche contributions to oncogenesis: emerging concepts and implications for the hematopoietic system.

@article{Raaijmakers2011NicheCT,
  title={Niche contributions to oncogenesis: emerging concepts and implications for the hematopoietic system.},
  author={Marc H. G. P. Raaijmakers},
  journal={Haematologica},
  year={2011},
  volume={96 7},
  pages={1041-8}
}
The field of hematopoietic oncology has traditionally focused on the study of hematopoietic cell autonomous genetic events in an effort to understand malignant transformation and develop therapeutics. Although highly rewarding in both aspects, this cell autonomous approach has failed to fully satisfy our need to understand tumor cell behavior and related clinical observations. In recent years, it has been increasingly recognized that the tumor microenvironment plays a pivotal role in cancer… CONTINUE READING

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