Nicastrin functions as a gamma-secretase-substrate receptor.

  title={Nicastrin functions as a gamma-secretase-substrate receptor.},
  author={Sanjiv J. Shah and S J Lee and Katsuhiko Tabuchi and Y Hao and Cong Yu and Quincey Laplant and Haydn Ball and Charles E. Dann and Thomas C S{\"u}dhof and Gang Yu},
  volume={122 3},
gamma-secretase catalyzes the intramembrane cleavage of amyloid precursor protein (APP) and Notch after their extracellular domains are shed by site-specific proteolysis. Nicastrin is an essential glycoprotein component of the gamma-secretase complex but has no known function. We now show that the ectodomain of nicastrin binds the new amino terminus that is generated upon proteolysis of the extracellular APP and Notch domains, thereby recruiting the APP and Notch substrates into the gamma… CONTINUE READING

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