Corpus ID: 27213829

Niacinamide-containing facial moisturizer improves skin barrier and benefits subjects with rosacea.

@article{Draelos2005NiacinamidecontainingFM,
  title={Niacinamide-containing facial moisturizer improves skin barrier and benefits subjects with rosacea.},
  author={Zoe Diana Draelos and Keith D. Ertel and Cynthia A Berge},
  journal={Cutis},
  year={2005},
  volume={76 2},
  pages={
          135-41
        }
}
A growing body of literature suggests that some moisturizers can improve stratum corneum barrier function, as well as ameliorate dry skin. [...] Key Method This randomized, investigator-blind, controlled observational study (N = 50) was designed to assess whether a niacinamide-containing facial moisturizer would improve the stratum corneum barrier and thus provide a clinical benefit to subjects with rosacea.Expand
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In double-blind studies moisturizers with urea have been shown to reduce TEWL in atopic and ichthyotic patients and ceramide-dominant lipid mixture improved atopic dermatitis and decreased transepidermal water loss in an open-label study in children. Expand
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All 6 moisturizers were found to accelerate regeneration of the skin barrier function when compared to irritated non‐treated skin, and the most lipid‐rich moisturizers improved barrier restoration more rapidly than the less lipid‐ rich moisturizers. Expand
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Certain moisturizers could improve skin barrier function in atopics and reduce skin susceptibility to irritants, as measured by TEWL and superficial skin blood flow. Expand
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Objective biophysical measurements could detect differences in barrier function between those individuals who identified themselves as having sensitive skin and those self-identified as having normal skin to determine skin sensitivity. Expand
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Sensitive skin has been described as a skin type showing higher reactivity than normal skin and developing exaggerated reactions when exposed to external factors. The stinging test, performed byExpand
Nicotinamide increases biosynthesis of ceramides as well as other stratum corneum lipids to improve the epidermal permeability barrier
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Nicotinamide improved the permeability barrier by stimulating de novo synthesis of ceramides, with upregulation of serine palmitoyltransferase (SPT) and other intercellular lipids. Expand
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Glycerol can be regarded as a barrier stabilizing and moisturizing compound as the glycerol-induced recovery of barrier function and stratum corneum hydration were observed even 7 days after the end of treatment. Expand
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Comparing the ability of complete physiologic lipid mixtures vs a nonmetabolized hydrophobic lipid, petrolatum, to repair the barrier and the requirement for intracellular processing of these lipids within the epidermis found that petrolatum produces more rapid improvement in barrier function than the solvent-dispersed physiologic lipids. Expand
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