Niacinamide - Mechanisms of Action and Its Topical Use in Dermatology

@article{Wohlrab2014NiacinamideM,
  title={Niacinamide - Mechanisms of Action and Its Topical Use in Dermatology},
  author={Johannes Wohlrab and Daniel Kreft},
  journal={Skin Pharmacology and Physiology},
  year={2014},
  volume={27},
  pages={311 - 315}
}
Niacinamide, an amide of vitamin B3 (niacin), is a hydrophilic endogenous substance. Its effects after epicutaneous application have long been described in the literature. Given a sufficient bioavailability, niacinamide has antipruritic, antimicrobial, vasoactive, photo-protective, sebostatic and lightening effects depending on its concentration. Within a complex metabolic system niacinamide controls the NFκB-mediated transcription of signalling molecules by inhibiting the nuclear poly (ADP… 
NIACINAMIDE AND DERMATOLOGY
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