Niacin stimulates adiponectin secretion through the GPR109A receptor.

  title={Niacin stimulates adiponectin secretion through the GPR109A receptor.},
  author={Eric P Plaisance and Martina Lukasova and Stefan Offermanns and Youyan Zhang and Guoqing Cao and Robert L. Judd},
  journal={American journal of physiology. Endocrinology and metabolism},
  volume={296 3},
Niacin (nicotinic acid) has recently been shown to increase serum adiponectin concentrations in men with the metabolic syndrome. However, little is known about the mechanism(s) by which niacin regulates the intracellular trafficking and secretion of adiponectin. Since niacin appears to exert its effects on lipolysis through receptor (GPR109A)-dependent and -independent pathways, the purpose of this investigation was to examine the role of the recently identified GPR109A receptor in adiponectin… CONTINUE READING


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Analogues of acifran : agonists of the high and low affinity niacin receptors , GPR 109 a and GPR 109 b

  • L Kang, LE Nagy
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