Niacin stimulates adiponectin secretion through the GPR109A receptor.

@article{Plaisance2009NiacinSA,
  title={Niacin stimulates adiponectin secretion through the GPR109A receptor.},
  author={Eric P. Plaisance and Martina Luk{\'a}{\vs}ov{\'a} and Stefan Offermanns and Youyan Zhang and Guoqing Cao and Robert L. Judd},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2009},
  volume={296 3},
  pages={
          E549-58
        }
}
Niacin (nicotinic acid) has recently been shown to increase serum adiponectin concentrations in men with the metabolic syndrome. However, little is known about the mechanism(s) by which niacin regulates the intracellular trafficking and secretion of adiponectin. Since niacin appears to exert its effects on lipolysis through receptor (GPR109A)-dependent and -independent pathways, the purpose of this investigation was to examine the role of the recently identified GPR109A receptor in adiponectin… 
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This review presents what is known to date about G PR109A biology and function and the future of GPR109A as a pharmacological target and suggests it could play a crucial part in its role as a lipid‐modifying drug.
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Adipose tissue secretes multiple metabolically important proteins known as adipokines. One of the most abundant adipokines in circulation is adiponectin (AdipoQ), which is known as an important…
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Niacin in Cardiovascular Disease: Recent Preclinical and Clinical Developments
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The recent reports of anti-inflammatory effects of niacin in adipocytes and through bone marrow derived cells and vascular endothelium are discussed, and mechanisms of action on lipoproteins, which remain complex and incompletely understood are reviewed.
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