Niacin inhibits vascular oxidative stress, redox-sensitive genes, and monocyte adhesion to human aortic endothelial cells.

@article{Ganji2009NiacinIV,
  title={Niacin inhibits vascular oxidative stress, redox-sensitive genes, and monocyte adhesion to human aortic endothelial cells.},
  author={Shobha H. Ganji and Shucun Qin and Linhua Zhang and Vaijinath S. Kamanna and Moti L. Kashyap},
  journal={Atherosclerosis},
  year={2009},
  volume={202 1},
  pages={
          68-75
        }
}
  • Shobha H. Ganji, Shucun Qin, +2 authors Moti L. Kashyap
  • Published in Atherosclerosis 2009
  • Medicine
  • In pharmacological doses, nicotinic acid (niacin) reduces myocardial infarction, stroke and atherosclerosis. The beneficial effects of niacin on lipoproteins are thought to mediate these effects. We hypothesized that niacin inhibits oxidative stress and redox-sensitive inflammatory genes that play a critical role in early atherogenesis. In cultured human aortic endothelial cells (HAEC), niacin increased nicotinamide adenine dinucleotide phosphate (NAD(P)H) levels by 54% and reduced glutathione… CONTINUE READING

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