Niacin-induced “Flush” Involves Release of Prostaglandin D2 from Mast Cells and Serotonin from Platelets: Evidence from Human Cells in Vitro and an Animal Model

@article{Papaliodis2008NiacininducedI,
  title={Niacin-induced “Flush” Involves Release of Prostaglandin D2 from Mast Cells and Serotonin from Platelets: Evidence from Human Cells in Vitro and an Animal Model},
  author={D. Papaliodis and W. Boucher and D. Kempuraj and M. Michaelian and A. Wolfberg and M. House and T. Theoharides},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2008},
  volume={327},
  pages={665 - 672}
}
Niacin lowers serum cholesterol, low-density lipoprotein, and triglycerides, and it raises high-density lipoprotein. However, most patients experience cutaneous warmth and vasodilation (flush). Acetylsalicylic acid (ASA) can reduce this flush, presumably by decreasing prostaglandin D2 (PGD2) release from macrophages. Here, we show that methylnicotinate induces significant PGD2 release from human mast cells and serotonin from human platelets. Intradermal injection of methylnicotinate induces rat… Expand
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