Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy.

W. Boden; J. Probstfield; T. Anderson; B. Chaitman; Patrice Desvignes-Nickens; K. Koprowicz; R. Mcbride; K. Teo; W. Weintraub

DOI:10.1056/NEJMoa1107579

Corpus ID: 12844039

Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy.

@article{Boden2011NiacinIP,
  title={Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy.},
  author={W. Boden and J. Probstfield and T. Anderson and B. Chaitman and Patrice Desvignes-Nickens and K. Koprowicz and R. Mcbride and K. Teo and W. Weintraub},
  journal={The New England journal of medicine},
  year={2011},
  volume={365 24},
  pages={
          2255-67
        }
}

W. Boden, J. Probstfield, +6 authors W. Weintraub

Published 2011

Medicine

The New England journal of medicine

BACKGROUND In patients with established cardiovascular disease, residual cardiovascular risk persists despite the achievement of target low-density lipoprotein (LDL) cholesterol levels with statin therapy. It is unclear whether extended-release niacin added to simvastatin to raise low levels of high-density lipoprotein (HDL) cholesterol is superior to simvastatin alone in reducing such residual risk. METHODS We randomly assigned eligible patients to receive extended-release niacin, 1500 to… CONTINUE READING

View PDF

Share This Paper

2,229 Citations

Highly Influential Citations

Background Citations

496

Methods Citations

Results Citations

Supplemental Clinical Trials

Interventional Clinical Trial

Niacin Plus Statin to Prevent Vascular Events

The purpose of this study is to determine whether raising "good cholesterol" with a drug based on the vitamin niacin, while lowering "bad cholesterol" with a statin drug, can prevent… Expand

Conditions	Atherosclerosis, Cardiovascular Diseases, Cerebrovascular Accident, (+3 more)
Intervention	Drug

Axio Research. LLC

September 2005 - December 2012

Explore Further

Discover more papers related to the topics discussed in this paper

Figures, Tables, and Topics from this paper

Figures and Tables

Paper Mentions

Interventional Clinical Trial

Effects of Short-term Diet on HDL Composition and Function

The primary objective of this study is to generate preliminary data on the effects of a short-term diet of either fast food or Mediterranean type diet on HDL and microbiota… Expand

Conditions	Diet Modification, HDL, Inflammation
Intervention	Other

University of California, Davis

March 2016 - August 2026

Observational Clinical Trial

Lp(a) and Aortic Valve Calcification

Aortic valve stenosis (AVS), the most common form of valve disease in the western world, afflicts more than 1 million individuals in North America [1] and the burden of AVS is high… Expand

Conditions	Heterozygous Familial Hypercholesterolemia

Laval University

April 2017 - February 2020

News Article

5 Lipid-Lowering Studies Pharmacists Should Know About, Part 2

Pharmacy Times

1 May 2019

Interventional Clinical Trial

Effect of Pravastatin on Erythrocyte Membrane Fatty Acid Contents in Patients With Chronic Kidney Disease

Treatment using statin has been decreased the risk of cardiovascular events in pre-dialysis CKD population. Supplementation with omega-3 fatty acid (FA) lowers the risk of… Expand