Ni2+ Block of CaV3.1 (α1G) T-type Calcium Channels

@article{ObejeroPaz2008Ni2BO,
  title={Ni2+ Block of CaV3.1 (α1G) T-type Calcium Channels},
  author={Carlos A. Obejero-Paz and I. Patrick Gray and Stephen W. Jones},
  journal={The Journal of General Physiology},
  year={2008},
  volume={132},
  pages={239 - 250}
}
Ni(2+) inhibits current through calcium channels, in part by blocking the pore, but Ni(2+) may also allosterically affect channel activity via sites outside the permeation pathway. As a test for pore blockade, we examined whether the effect of Ni(2+) on Ca(V)3.1 is affected by permeant ions. We find two components to block by Ni(2+), a rapid block with little voltage dependence, and a slow block most visible as accelerated tail currents. Rapid block is weaker for outward vs. inward currents… CONTINUE READING
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