Ni-Catalyzed Regioselective Alkenylarylation of γ,δ-Alkenyl Ketones via Carbonyl Coordination.

@article{Dhungana2021NiCatalyzedRA,
  title={Ni-Catalyzed Regioselective Alkenylarylation of $\gamma$,$\delta$-Alkenyl Ketones via Carbonyl Coordination.},
  author={Roshan K. Dhungana and Vivek Aryal and Doleshwar Niroula and Rishi R Sapkota and Margaret G. Lakomy and Ramesh Giri},
  journal={Angewandte Chemie},
  year={2021}
}
We disclose a nickel-catalyzed reaction, which enabled us to difunctionalize unactivated γ,δ-alkenes in ketones with alkenyl triflates and arylboronic esters. The reaction was made feasible by the use of 5-chloro-8-hydroxyquinoline as a ligand along with NiBr 2 •DME as a catalyst and LiO t Bu as base. The reaction proceeded with a wide range of cyclic, acyclic, endocyclic and exocyclic alkenyl ketones, and electron-rich and electron-deficient arylboronate esters. The reaction also worked with… 
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