Ni-Catalyzed Regioselective 1,2-Dialkylation of Alkenes Enabled by the Formation of Two C(sp3)-C(sp3) Bonds.

@article{Dhungana2020NiCatalyzedR1,
  title={Ni-Catalyzed Regioselective 1,2-Dialkylation of Alkenes Enabled by the Formation of Two C(sp3)-C(sp3) Bonds.},
  author={Roshan K. Dhungana and Rishi R Sapkota and Laura M. Wickham and Doleshwar Niroula and Ramesh Giri},
  journal={Journal of the American Chemical Society},
  year={2020}
}
We disclose a Ni-catalyzed vicinal difunctionalization of alkenes with benzyl halides and alkylzinc reagents, which produces products with two new alkyl-alkyl bonds. This alkene dialkylation is effective in combining secondary benzyl halides and secondary alkylzinc reagents with internal alkenes, which furnishes products with three contiguous all-carbon secondary stereocenters. The products can be readily elaborated to access complex tetralene, benzosuberene, and bicyclodecene cores. The… 
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12 Citations

12 Citations

Citation Type

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