Ni(II)/BINOL-catalyzed alkenylation of unactivated C(sp(3))-H bonds.

  title={Ni(II)/BINOL-catalyzed alkenylation of unactivated C(sp(3))-H bonds.},
  author={Yue‐Jin Liu and Zhuo-Zhuo Zhang and Shengyi Yan and Yan-Hua Liu and Bing‐Feng Shi},
  journal={Chemical communications},
  volume={51 37},
The first nickel-catalyzed alkenylation of unactivated C(sp(3))-H bonds with vinyl iodides is described. The catalytic system comprises an inexpensive and air-stable Ni(acac)2 as the catalyst and BINOL as the ligand, which is highly efficient for the alkenylation of β-methyl C(sp(3))-H bonds of a broad range of aliphatic carboxamides. The resulting olefins can serve as versatile handles for further preparation. Additionally, we also demonstrated the synthesis of functionalized carboxamides… 
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