Ngn2 and Nurr1 act in synergy to induce midbrain dopaminergic neurons from expanded neural stem and progenitor cells.

@article{Andersson2007Ngn2AN,
  title={Ngn2 and Nurr1 act in synergy to induce midbrain dopaminergic neurons from expanded neural stem and progenitor cells.},
  author={Elin K I Andersson and Dwain K. Irvin and Jessica Ahlsi{\"o} and Malin Parmar},
  journal={Experimental cell research},
  year={2007},
  volume={313 6},
  pages={1172-80}
}
Parkinson's Disease (PD) is a debilitating motor function disorder due primarily to a loss of midbrain dopaminergic neurons and a subsequent reduction in dopaminergic innervation of the striatum. Several attempts have been made to generate dopaminergic neurons from progenitor cell populations in vitro for potential use in cell replacement therapy for PD. However, expanding cells from fetal brain with retained potential for dopaminergic differentiation has proven to be difficult. In this study… CONTINUE READING
30 Citations
40 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 30 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 40 references

Similar Papers

Loading similar papers…