NgR1 and NgR3 are Receptors for Chondroitin Sulfate Proteoglycans

@inproceedings{Dickendesher2012NgR1AN,
  title={NgR1 and NgR3 are Receptors for Chondroitin Sulfate Proteoglycans},
  author={Travis L. Dickendesher and Katherine T. Baldwin and Yevgeniya A. Mironova and Yoshiki Koriyama and Stephen J. Raiker and Kim L. Askew and Andrew C. Wood and Cedric G Geoffroy and Binhai Zheng and Claire D. Liepmann and Yasuhiro Katagiri and Larry Benowitz and Herbert M Geller and Roman J Giger},
  booktitle={Nature Neuroscience},
  year={2012}
}
In the adult mammalian CNS, chondroitin sulfate proteoglycans (CSPGs) and myelin-associated inhibitors (MAIs) stabilize neuronal structure and restrict compensatory sprouting following injury. The Nogo receptor family members NgR1 and NgR2 bind to MAIs and have been implicated in neuronal inhibition. We found that NgR1 and NgR3 bind with high affinity to the glycosaminoglycan moiety of proteoglycans and participate in CSPG inhibition in cultured neurons. Nogo receptor triple mutants (Ngr1… CONTINUE READING
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