Nfib Promotes Metastasis through a Widespread Increase in Chromatin Accessibility

  title={Nfib Promotes Metastasis through a Widespread Increase in Chromatin Accessibility},
  author={Sarah Knight Denny and Dian Yang and Chen-Hua Chuang and Jennifer J. Brady and Jing Shan Lim and Barbara M Gr{\"u}ner and Shin-Heng Chiou and Alicia N. Schep and Jessika Baral and C{\'e}cile Hamard and Martine Antoine and Marie Wislez and Christina S. Kong and Andrew J. Connolly and Kwon-Sik Park and Julien Sage and William J Greenleaf and Monte M Winslow},
Metastases are the main cause of cancer deaths, but the mechanisms underlying metastatic progression remain poorly understood. We isolated pure populations of cancer cells from primary tumors and metastases from a genetically engineered mouse model of human small cell lung cancer (SCLC) to investigate the mechanisms that drive the metastatic spread of this lethal cancer. Genome-wide characterization of chromatin accessibility revealed the opening of large numbers of distal regulatory elements… CONTINUE READING
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