Nfatc2 and Tob1 Have Non-Overlapping Function in T Cell Negative Regulation and Tumorigenesis

@inproceedings{May2014Nfatc2AT,
  title={Nfatc2 and Tob1 Have Non-Overlapping Function in T Cell Negative Regulation and Tumorigenesis},
  author={Sarah L. May and Qing Sheng Zhou and Mitzi Lewellen and Cristan M. Carter and David Coffey and Steven L Highfill and Christoph Marcus Bucher and Ilze Matise and Herbert C. Morse and Michael G. O’Sullivan and Melissa M. Schutten and Charles Johnson and Donald Bellgrau and Bruce R Blazar and Jaime F Modiano},
  booktitle={PloS one},
  year={2014}
}
Nfatc2 and Tob1 are intrinsic negative regulators of T cell activation. Nfatc2-deficient and Tob1-deficient T cells show reduced thresholds of activation; however, whether these factors have independent or overlapping roles in negative regulation of T cell responses has not been previously examined. Here, we show that Nfatc2 knockout (KO) but not Tob1 KO mice have age-associated accumulation of persistently activated T cells in vivo and expansion of the CD44+ memory cell compartment and age… CONTINUE READING
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