Nf1 limits epicardial derivative expansion by regulating epithelial to mesenchymal transition and proliferation.

@article{Baek2012Nf1LE,
  title={Nf1 limits epicardial derivative expansion by regulating epithelial to mesenchymal transition and proliferation.},
  author={Seung Tae Baek and Michelle D Tallquist},
  journal={Development},
  year={2012},
  volume={139 11},
  pages={
          2040-9
        }
}
The epicardium is the primary source of coronary vascular smooth muscle cells (cVSMCs) and fibroblasts that reside in the compact myocardium. To form these epicardial-derived cells (EPDCs), the epicardium undergoes the process of epithelial to mesenchymal transition (EMT). Although several signaling pathways have been identified that disrupt EMT, no pathway has been reported that restricts this developmental process. Here, we identify neurofibromin 1 (Nf1) as a key mediator of epicardial EMT… CONTINUE READING

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