Nf1 Regulates Hematopoietic Progenitor Cell Growth and Ras Signaling in Response to Multiple Cytokines

@article{Zhang1998Nf1RH,
  title={Nf1 Regulates Hematopoietic Progenitor Cell Growth  and Ras Signaling in Response to Multiple Cytokines },
  author={You-Yan Zhang and Terry A. Vik and John W. Ryder and Edward F Srour and Tyler Jacks and Kevin Shannon and D. Wade Clapp},
  journal={The Journal of Experimental Medicine},
  year={1998},
  volume={187},
  pages={1893 - 1902}
}
Neurofibromin, the protein encoded by the NF1 tumor-suppressor gene, negatively regulates the output of p21(ras) (Ras) proteins by accelerating the hydrolysis of active Ras-guanosine triphosphate to inactive Ras-guanosine diphosphate. Children with neurofibromatosis type 1 (NF1) are predisposed to juvenile chronic myelogenous leukemia (JCML) and other… CONTINUE READING